We recently published a study for calculating an optimal threshold for protein homology detection. This methods only uses intrinsic information of the dataset and requires no additional expert knowledge. We demonstrated that approach on the homology detection of 79 actinobacteria. For further information, please refer to the original paper:
Welcome to the supplementary website of "Density Parameter Estimation for Finding Clusters of Homologous Proteins - Tracing Actinobacterial Pathogenicity Life Styles". Please use the links on the left side or below to download the additional figures or the supplementary datasets.